According to the scientific data this may work for shiba inus but will help your dogs compex diseases? The author goes into great detail about why and how, but is this exclusive to shiba inus or across all breeds? Take a look…
This May Work For Shiba Inus But Will Help Your Dogs Complex Diseases
Microbes have recently gained significant attention due to their crucial role and therapeutic potential in addressing common complex diseases, such as atopic dermatitis in humans. Dysbiosis (imbalance in the community of microbes) in the skin has been the most well addressed in human AD patients. Scientists from the Lübeck Institute of Experimental Dermatology at the University of Lübeck, together with colleagues at Tokyo University of Agriculture and Technologies and Royal Canine SAS systematically described compositions of microbes residing on the skin and in the gut from adult Shiba Inu dogs. Shiba Inu is a canine breed known to be highly susceptible to cAD, particularly in Japan. To analyze the microbiome, researchers took skin swab samples from 12 skin sites per dog in addition to stool samples from four different Shiba Inu dog groups; (1) newly diagnosed cAD dogs without treatment, (2) the same cAD dogs after receiving Janus kinase antagonist (Oclacitinib; Apoquel®) for 2 weeks (0.4-0.6 mg/kg, twice daily), (3) cAD dogs with long-term Oclacitinib treatment (0.4-0.6 mg/kg, once a day) and (4) healthy dogs, and profiled the bacterial composition by using bacterial 16S rRNA gene sequencing. With this experimental design, they compared the microbiome of cAD-affected dogs to that of healthy dogs, and they evaluated the impact of treatment with Oclacitinib on the changes in the microbiota. Apoquel® is a veterinary used drug to treat pruritis associated with allergic skin inflammation including cAD, and it blocks the action of enzymes Janus kinases, which mediate itchiness and the inflammation.
The most prominent finding of the study is that Fusobacteria and Megamonas are highly abundant in healthy dogs but significantly reduced in cAD-affected dogs. After receiving Oclacitinib this bacterial abundance in cAD-affected dogs was reverted towards the levels of healthy dogs. Interestingly, the change of the microbiota caused by the treatment was more prominent in the gut than that on the skin. These results indicate that microbes serve as potential therapeutic targets and biomarkers for cAD. In addition, the researchers performed canine whole mitochondrial DNA sequencing of buccal swab samples obtained from the dogs. For the first time, this study revealed an association of dog mitochondrial haplogroups, i.e., a combination of genetic variations in the mitochondrial DNA, with specific bacterial taxa in the skin and gut.
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So after reading this this may work for shiba inus but will help your dogs compex diseases is a legitimate question! What answer did you come up with for your best friend? Will this work? Let us know below in the comment section…
